Relationship of Helicobacter Pylori Specific IgG Antibodies with Serum Magnesium in Patients on Maintenance Hemodialysis
نویسنده
چکیده
Dyspeptic symptoms are quite common in patients on long-term hemodialysis, and Helicobacter pylori is thought to play an important role in the pathogenesis of active gastritis and other upper gastrointestinal mucosal lesions in these patients. This study investigated the probable association of serum magnesium (Mg2+) with H pylori infection in patients on maintenance therapy. H pylori specific IgG antibody titers and Mg2+ levels were measured in 44 patients on hemodialysis (34 nondiabetic and 10 diabetic). A positive correlation was found between anti H pylori IgG antibody titers with Mg2+ in all patients, as well as an association between Mg2+ with infection of H pylori. This study found Mg2+ acquisition by CorA is essential for H pylori in vitro and that high Mg2+ levels, and probably its higher concentration in gastric mucosa, might facilitate the colonization of H pylori in the stomachs of patients on hemodialysis. Further investigation is needed to 14Nasri-vol5no3 1/26/70 6:31 PM Page 438
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